The star quarterback — who is still dealing with a calf strain, so not guaranteed to even play — gets a difficult draw against a run-funneling Minnesota defense that ranks third in pass DVOA. On the season, the Vikings have managed to pressure opposing quarterbacks 32 per cent of the time, producing a sack rate of 9.3 per cent (both ranked first in the league). Owners should expect a pseudo pitch count for Prescott and a heavier tilt towards the run game.

Despite the old mantra “never bet against Tom Brady,” a lingering thumb injury and poor second half play against Philadelphia dampens our expectations of the HOF quarterback to a QB2 performance this week.

More importantly, Seattle’s pass defense against running backs has been equally anemic, coughing up 33 receptions on 38 targets for 314 yards.

Green has accumulated 83.1 per cent snap count, 86.3 route participation and 18 per cent target share through four games while matching Hopkins’ stat line (15-248-2 for Green vs. 17-225-3 for Hopkins). With Hopkins nursing a rib injury over the last couple of games, we expect Green to maintain his usage against a stunted San Francisco secondary.